Unravelling fibrosis using single-cell transcriptomics

Abstract

Fibrosis, the excessive accumulation of extracellular matrix, is a major global healthcare burden. Despite major advances in our understanding of the mechanisms regulating fibrosis, treatment options for patients with fibrosis remain very limited. However, recent developments in the rapidly evolving field of single-cell transcriptomics are enabling the interrogation of individual pathogenic cell populations in the context of fibrosis at unprecedented resolution. In this review, we will discuss how single-cell transcriptomics is driving this step change in our understanding of fibrotic disease pathogenesis, and how these cutting-edge approaches should accelerate the precise identification of novel, relevant and potentially druggable therapeutic targets to treat patients with fibrosis.