Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity

Mara De Martino; Claire Vanpouille-Box

doi:10.1016/j.tcb.2019.09.001

Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity

Trends Cell Biol. 2019 Nov;29(11):851-853. doi: 10.1016/j.tcb.2019.09.001. Epub 2019 Oct 14.

Authors

Mara De Martino¹, Claire Vanpouille-Box²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
² Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. Electronic address: clv2002@med.cornell.edu.

PMID: 31623928
DOI: 10.1016/j.tcb.2019.09.001

Abstract

In a recent study in Oncoimmunology, Rodriguez-Ruiz et al. demonstrate that the apoptotic executioner caspase 3 (CASP3) attenuates antitumor immune responses induced by radiation therapy (RT) by inhibiting the release of cytosolic DNA. CASP3 stands out as a promising target for the development of novel strategies to improve anticancer responses driven by RT.

Keywords: CASP3; CGAS; SLC7A2; immune checkpoint blockers; mitochondrial outer membrane permeabilization; radiation therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / physiology*
Caspase 3 / metabolism*
Cell Proliferation / physiology
DNA, Mitochondrial / genetics
Humans
Interferon Type I / immunology
Mice
Neoplasms / immunology*
Neoplasms / radiotherapy*
T-Lymphocytes / metabolism

Substances

DNA, Mitochondrial
Interferon Type I
CASP3 protein, human
Caspase 3