Abstract
NIR-II fluorescence imaging has great potential in diagnosis, but the quantum efficiency of contrast agents is an urgent problem to be solved. We synthesized two new multifunctional polymers, P-TT and P-DPP, with a tetrahedral C (sp3) and branched alkyl chains in the main chain, which were beneficial to obtain high quantum efficiency. P-TT and P-DPP showed absorption peaks of 686 nm and 763 nm, respectively, and fluorescence emission peaks of 1071 nm and 1066 nm, respectively. The photothermal effect of P-DPP can reach 52 °C, and the quantum yield reaches 1.5%, which was three times higher than that of nanotube fluorophores (quantum yield 0.4%). P-DPP is used for stable fluorescence imaging of blood vessels and photoacoustic imaging of nude mice, and successfully applied to phototherapy of nude mouse tumours.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Female
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Fluorescent Dyes
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HeLa Cells
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Humans
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Hyperthermia, Induced / methods
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Infrared Rays
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Liver / diagnostic imaging
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Mice, Nude
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Nanoparticles / radiation effects
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Nanoparticles / therapeutic use*
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Nanoparticles / toxicity
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Neoplasms / diagnostic imaging*
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Neoplasms / drug therapy*
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Photoacoustic Techniques / methods
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Photochemotherapy / methods
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Polymers / chemical synthesis
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Polymers / radiation effects
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Polymers / therapeutic use*
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Polymers / toxicity
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Thiophenes / chemical synthesis
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Thiophenes / radiation effects
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Thiophenes / therapeutic use*
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Thiophenes / toxicity
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Polymers
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Thiophenes