Abstract
Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases.
Keywords:
DNA translocase; SMC complexes; chromosome segregation; loop extrusion; sister chromatid cohesion.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphatases / metabolism
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Animals
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Cell Cycle Proteins / metabolism
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Chromatids* / chemistry
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Chromatids* / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Chromosome Segregation
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Chromosomes / chemistry
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Chromosomes / genetics
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Chromosomes / metabolism*
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Cohesins
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DNA / chemistry*
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DNA / metabolism*
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DNA-Binding Proteins / metabolism
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Enhancer Elements, Genetic
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Mitosis
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism*
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Promoter Regions, Genetic
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V(D)J Recombination
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Multiprotein Complexes
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condensin complexes
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DNA
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Adenosine Triphosphatases