Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

Liansheng Zhao; Huijuan Wang; Yamin Zhang; Jinxue Wei; Peiyan Ni; Hongyan Ren; Gang Li; Qiang Wang; Gavin P Reynolds; Weihua Yue; Wei Deng; Hao Yan; Liwen Tan; Qi Chen; Guigang Yang; Tianlan Lu; Lifang Wang; Fuquan Zhang; Jianli Yang; Keqing Li; Luxian Lv; Qingrong Tan; Yinfei Li; Hua Yu; Hongyan Zhang; Xin Ma; Fude Yang; Lingjiang Li; Chuanyue Wang; Huiyao Wang; Xiaojing Li; Wanjun Guo; Xun Hu; Yang Tian; Xiaohong Ma; Jeremy Coid; Dai Zhang; Chao Chen; Tao Li; Chinese Antipsychotics Pharmacogenomics Consortium

doi:10.1007/s12264-019-00432-2

Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

Neurosci Bull. 2019 Dec;35(6):1102-1105. doi: 10.1007/s12264-019-00432-2. Epub 2019 Sep 30.

Authors

Liansheng Zhao^{1

2}, Huijuan Wang³, Yamin Zhang^{1

2}, Jinxue Wei^{1

2}, Peiyan Ni^{1

2}, Hongyan Ren^{1

2}, Gang Li⁴, Qiang Wang^{1

2}, Gavin P Reynolds⁵, Weihua Yue^{6

7}, Wei Deng^{1

2}, Hao Yan^{6

7}, Liwen Tan⁸, Qi Chen⁹, Guigang Yang¹⁰, Tianlan Lu^{6

7}, Lifang Wang^{6

7}, Fuquan Zhang¹¹, Jianli Yang^{12

13}, Keqing Li¹⁴, Luxian Lv¹⁵, Qingrong Tan¹⁶, Yinfei Li^{1

2}, Hua Yu^{1

2}, Hongyan Zhang^{6

7}, Xin Ma⁹, Fude Yang¹⁰, Lingjiang Li⁸, Chuanyue Wang⁹, Huiyao Wang^{1

2}, Xiaojing Li^{1

2}, Wanjun Guo^{1

2}, Xun Hu¹⁷, Yang Tian^{1

2}, Xiaohong Ma^{1

2}, Jeremy Coid^{1

2}, Dai Zhang^{6

7}, Chao Chen¹⁸, Tao Li^{19

20}; Chinese Antipsychotics Pharmacogenomics Consortium

Affiliations

¹ Psychiatric Laboratory and Mental Health Center, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China.
² West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, 610041, China.
³ The National Engineering Research Center for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, 710069, China.
⁴ Shaanxi Lifegen Co., Ltd, Xi'an, 712000, China.
⁵ Biomolecular Science Research Centre, Sheffield Hallam University, Sheffield, S11WB, UK.
⁶ Peking University Sixth Hospital (Institute of Mental Health), Beijing, 100083, China.
⁷ National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 100871, China.
⁸ Second Xiangya Hospital, Central South University, Changsha, 410011, China.
⁹ Beijing Anding Hospital, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100088, China.
¹⁰ Beijing HuiLongGuan Hospital, Beijing, 102200, China.
¹¹ Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214121, China.
¹² Institute of Mental Health, Tianjin Anding Hospital, Tianjin, 300222, China.
¹³ Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
¹⁴ Hebei Mental Health Center, Baoding, 071000, China.
¹⁵ Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China.
¹⁶ Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
¹⁷ Huaxi Biobank, West China Hospital of Sichuan University, Chengdu, 610041, China.
¹⁸ The National Engineering Research Center for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, 710069, China. chaochen@nwu.edu.cn.
¹⁹ Psychiatric Laboratory and Mental Health Center, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China. litaohx@scu.edu.cn.
²⁰ West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, 610041, China. litaohx@scu.edu.cn.

No abstract available

Publication types

Letter

MeSH terms

Antipsychotic Agents / therapeutic use*
Humans
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT2A / genetics*
Receptors, Dopamine D2 / genetics*
Schizophrenia / drug therapy*
Schizophrenia / genetics*
Treatment Outcome

Substances

Antipsychotic Agents
DRD2 protein, human
Receptor, Serotonin, 5-HT2A
Receptors, Dopamine D2