Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants

Pablo Dualde; Olga Pardo; Francisca Corpas-Burgos; Julia Kuligowski; María Gormaz; Máximo Vento; Agustín Pastor; Vicent Yusà

doi:10.1016/j.chemosphere.2019.124829

Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants

Chemosphere. 2020 Feb:240:124829. doi: 10.1016/j.chemosphere.2019.124829. Epub 2019 Sep 13.

Authors

Pablo Dualde¹, Olga Pardo², Francisca Corpas-Burgos², Julia Kuligowski³, María Gormaz⁴, Máximo Vento⁴, Agustín Pastor⁵, Vicent Yusà⁶

Affiliations

¹ Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020, Valencia, Spain; Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100, Burjassot, Spain.
² Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020, Valencia, Spain.
³ Neonatal Research Unit, Health Research Institute La Fe, Avenida Fernando Abril Martorell 106, 46026, Valencia, Spain.
⁴ Neonatal Division at the University and Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell, 106, 46026, Valencia, Spain.
⁵ Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100, Burjassot, Spain.
⁶ Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020, Valencia, Spain; Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100, Burjassot, Spain; Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020, Valencia, Spain. Electronic address: yusa_vic@gva.es.

PMID: 31563722
DOI: 10.1016/j.chemosphere.2019.124829

Abstract

In this study, we assessed the presence of four parabens in human milk of 120 mothers from Valencia (Spain) which took part in a human biomonitoring project (BETTERMILK). The detection frequency ranges of parabens were 41-60% and 61-89% for unconjugated- and total (unconjugated + conjugated)-parabens, respectively. The concentrations ranged from <LoQ to 31 ng/mL and from <LoQ to 49 ng/mL for unconjugated- and total-parabens, respectively. The frequency of use of some cosmetic products and human milk protein levels were the main predictors of parabens in milk. The study evidences the presence of both conjugated and unconjugated paraben forms in human milk. The newborns estimated daily intake of parabens through human milk was several orders of magnitude lower than the 0-10 mg/kg bw-day acceptable daily intake for the sum of methyl and ethyl paraben established by EFSA. To our knowledge, this is currently the largest biomonitoring study of parabens in human milk.

Keywords: Estimated daily intake; Human biomonitoring; Human milk; Infants; Mothers; Parabens.

MeSH terms

Biological Monitoring / methods*
Breast Feeding / methods*
Female
Humans
Infant
Infant, Newborn
Milk, Human / chemistry*
Parabens / chemistry*

Substances

Parabens