Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

Euro Surveill. 2019 Sep;24(38):1900557. doi: 10.2807/1560-7917.ES.2019.24.38.1900557.

Abstract

We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

Keywords: Chlamydia trachomatis; epidemiology; nucleic acid amplification testing.

MeSH terms

  • Adult
  • Chlamydia Infections / diagnosis*
  • Chlamydia Infections / epidemiology*
  • Chlamydia trachomatis / genetics*
  • Chlamydia trachomatis / isolation & purification*
  • England / epidemiology
  • False Positive Reactions
  • Female
  • Genetic Variation*
  • Humans
  • Male
  • Mass Screening / methods*
  • Nucleic Acid Amplification Techniques*
  • Prevalence
  • Young Adult