The number of patients with allergic rhinitis (AR) have been increasing in the world. Establishment of AR model in mice is an important method for the study of this disease. However, there is still no consensus standard for the modeling methods, selection of allergens and adjuvants, and evaluation parameter of AR modeling. Here, we introduce the advancement of AR mouse model in recent years from the above, and provide evidence of references for the standardized process of AR mouse model establishment.
变应性鼻炎（allergic rhinitis，AR）患者的数量逐年增加，在该病的研究过程中，AR小鼠造模是一个重要的组成部分。然而，国内外对于AR小鼠模型的造模方法、变应原、佐剂及模型判定参数仍然没有一个统一的标准。本文将从以上几个方面介绍AR小鼠造模方法近年来的进展，为AR造模的标准化和规范化提供参考资料。.
Keywords: Adjuvants, immunologic; Allergens; Mice; Models, animal; Rhinitis, allergic.