Clinical and epidemiological characteristics of childhood vitiligo: a study of 701 patients from Brazil

Int J Dermatol. 2020 Feb;59(2):236-244. doi: 10.1111/ijd.14645. Epub 2019 Sep 22.

Abstract

Background: Vitiligo is an acquired pigmentary disorder that affects approximately 0.5-2% of the world's population, and 25% of cases begin before 10 years of age. Although prevalent, there are few studies on the characterization of childhood vitiligo.

Objective: To evaluate the clinical and epidemiological characteristics of childhood vitiligo.

Methods: Transverse study conducted by reviewing data records of patients under the age of 18 in which disease onset occurred before 13 years of age.

Results: Predominance of females (62%). The most common subtype was generalized vitiligo (53.8%). The average age of disease onset was 5.9 years. The most affected initial site was head/neck (44.22%). The Koebner phenomenon was present in 38.2%, emotional triggering factors in 67.0% of the patients, halo nevus in 17.4%, and associated autoimmune disease in 6.5% of the patients. Family history of vitiligo was observed in 16.9% of the patients, and stability was reported by 20.1% of patients. The presence of positive family history did not significantly influence the age of onset. We found a significant difference between segmental vitiligo (SV) and nonsegmental vitiligo (NSV) regarding the age of onset, Koebner phenomenon, hypothyroidism, anti-TPO antibodies, family history of psoriasis, and halo nevus.

Conclusion: Childhood vitiligo has its own characteristics. Vitiligo different subtypes have distinct characteristics. Our study presents a great number of patients, helping to elucidate the peculiarities of childhood vitiligo in the Brazilian population.

MeSH terms

  • Adolescent
  • Age of Onset
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Comorbidity
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Nevus, Halo / epidemiology
  • Retrospective Studies
  • Vitiligo / epidemiology*
  • Vitiligo / etiology*
  • Vitiligo / genetics
  • Vitiligo / pathology