Phospholipid-based complex of raloxifene with enhanced biopharmaceutical potential: Synthesis, characterization and preclinical assessment

Int J Pharm. 2019 Nov 25:571:118698. doi: 10.1016/j.ijpharm.2019.118698. Epub 2019 Sep 17.

Authors

Atul Jain¹, Sumant Saini², Rajendra Kumar¹, Teenu Sharma², Rajan Swami¹, Om Prakash Katare², Bhupinder Singh³

Affiliations

¹ National UGC Centre of Excellence in NanoBiomedical Applications, Panjab University, Chandigarh 160014, India.
² University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
³ National UGC Centre of Excellence in NanoBiomedical Applications, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India. Electronic address: bsbhoop@pu.ac.in.

PMID: 31539555
DOI: 10.1016/j.ijpharm.2019.118698

No abstract available

MeSH terms

Animals
Apoptosis / drug effects
Caco-2 Cells
Cell Survival / drug effects
Drug Delivery Systems*
Drug Liberation
Erythrocytes / drug effects
Estrogen Antagonists / administration & dosage*
Estrogen Antagonists / chemistry
Estrogen Antagonists / pharmacokinetics
Female
Hemolysis / drug effects
Humans
MCF-7 Cells
Molecular Docking Simulation
Phospholipids / administration & dosage*
Phospholipids / chemistry
Phospholipids / pharmacokinetics
Raloxifene Hydrochloride / administration & dosage*
Raloxifene Hydrochloride / chemistry
Raloxifene Hydrochloride / pharmacokinetics
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism

Substances

Estrogen Antagonists
Phospholipids
Reactive Oxygen Species
Raloxifene Hydrochloride