Haemolytic uraemic syndrome associated with faecal cytotoxin and verotoxin neutralizing antibodies

Pediatr Nephrol. 1988 Jul;2(3):288-90. doi: 10.1007/BF00858679.

Abstract

Forty-nine patients with a diagnosis of idiopathic haemolytic uraemic syndrome (HUS) were investigated to determine evidence of infection by verotoxin-producing Escherichia coli (VTEC). Free faecal cytotoxin active on Vero cells (VT) was detected in 15 out of 49 patients (31%). Seroconversion or high titres of VT-neutralizing antibodies were detected in 11 out of 18 patients (61%). The results of the present study suggest an association between HUS and infection by VTEC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial*
  • Bacterial Toxins / immunology*
  • Child, Preschool
  • Cytotoxins / immunology
  • Escherichia coli / immunology
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / immunology
  • Feces / microbiology
  • Female
  • Hemolytic-Uremic Syndrome / complications
  • Hemolytic-Uremic Syndrome / immunology*
  • Humans
  • Infant
  • Male
  • Neutralization Tests
  • Shiga Toxin 1

Substances

  • Antibodies, Bacterial
  • Bacterial Toxins
  • Cytotoxins
  • Shiga Toxin 1