The elimination of caffeine from the plasma and the excretion of the major metabolites of metamizol (AnalginR) in the urine was studied in 25 women on long-term oral steroid contraceptives. Both tests allowed to draw conclusions about metabolic liver function. A steroid-induced delay of the elimination of caffeine in clinically healthy women with/without serologic elevation of aminotransferase activities was demonstrated. --We regard this as the consequence of an inhibition of the cytochrome P-450-dependent poly-functional oxidases of the P-450MC type, which was produced by oral contraceptives. The differences in the elimination of metamizol were not significant.
PIP: The elimination of caffeine from the plasma and the excretion of the major metabolites of metamizol (Analgin) in the urine was studied in 25 women on longterm oral contraceptives (OCs). Both tests allowed for conclusions about metabolic liver function. A steroid-induced delay of the elimination of caffeine in clinically healthy women with and without serologic elevation of aminotransferase activities was demonstrated. The author's regard this as the consequence of an inhibition of the cytochrome p-450-dependent polyfunctioned oxidases of the P-450 MC type, which was produced by OCs. The differences in the elimination of metamizol were not significant. (author's)