Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation

Alvaro A Ordonez; Mark A Sellmyer; Gayatri Gowrishankar; Camilo A Ruiz-Bedoya; Elizabeth W Tucker; Christopher J Palestro; Dima A Hammoud; Sanjay K Jain

doi:10.1126/scitranslmed.aax8251

Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation

Sci Transl Med. 2019 Sep 4;11(508):eaax8251. doi: 10.1126/scitranslmed.aax8251.

Authors

Alvaro A Ordonez^{1

2

3}, Mark A Sellmyer^{4

5}, Gayatri Gowrishankar⁶, Camilo A Ruiz-Bedoya^{1

2

3}, Elizabeth W Tucker^{1

3

7

8}, Christopher J Palestro⁹, Dima A Hammoud¹⁰, Sanjay K Jain^{11

2

3

12}

Affiliations

¹ Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
³ Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁴ Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
⁵ Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
⁶ Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁸ Division of Pediatric Critical Care, Johns Hopkins All Children's Hospital, St. Petersburg, FL 33701, USA.
⁹ Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
¹⁰ Center for Infectious Disease Imaging, Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD 20814, USA.
¹¹ Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. sjain5@jhmi.edu.
¹² Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

Clinical diagnostic tools requiring direct sample testing cannot be applied to infections deep within the body, and clinically available imaging tools lack specificity. New approaches are needed for early diagnosis and monitoring of bacterial infections and rapid detection of drug-resistant organisms. Molecular imaging allows for longitudinal, noninvasive assessments and can provide key information about infectious processes deep within the body.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Bacterial Infections / diagnosis
Bacterial Infections / diagnostic imaging*
Cost of Illness
Humans
Molecular Imaging*
Patient Selection
Precision Medicine
Translational Research, Biomedical*

Abstract

Publication types

MeSH terms

Grants and funding