Dioxazolones as masked ester surrogates in the Pd(ii)-catalyzed direct C-H arylation of 6,5-fused heterocycles

Paridhi Saxena; Neha Maida; Manmohan Kapur

doi:10.1039/c9cc05563k

Dioxazolones as masked ester surrogates in the Pd(ii)-catalyzed direct C-H arylation of 6,5-fused heterocycles

Chem Commun (Camb). 2019 Sep 17;55(75):11187-11190. doi: 10.1039/c9cc05563k.

Authors

Paridhi Saxena¹, Neha Maida, Manmohan Kapur

Affiliation

¹ Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal Bypass Road, Bhopal 462066, MP, India. mk@iiserb.ac.in.

PMID: 31465039
DOI: 10.1039/c9cc05563k

Abstract

A simple and effective Pd(ii)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions is reported. The significance of the arylation is highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions.