Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe2)3, PCl3, or P(OPh)3

Imen Talbi; Mohamed Lotfi Efrit; Soufiane Touil

doi:10.1021/acsomega.8b00544

Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe₂)₃, PCl₃, or P(OPh)₃

ACS Omega. 2018 May 9;3(5):5078-5082. doi: 10.1021/acsomega.8b00544. eCollection 2018 May 31.

Authors

Imen Talbi¹, Mohamed Lotfi Efrit², Soufiane Touil¹

Affiliations

¹ Laboratory of Heteroatom Organic Chemistry, Faculty of Sciences of Bizerte, University of Carthage, 7021 Zarzouna, Tunisia.
² Laboratoire de Synthèse Organique Sélective et Hétérocyclique-Evaluation de l'Activité Biologique, Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunis 2092, Tunisia.

Abstract

Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe₂)₃, PCl₃, or P(OPh)₃. The reactions were conducted under operationally simple and mild conditions and displayed broad substrate scope and good functional group tolerance.