Abstract
The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC50 value of 5.4 µM.
MeSH terms
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Actinobacteria / chemistry
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Actinobacteria / metabolism*
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Animals
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Anti-Bacterial Agents / pharmacology
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Biological Assay
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Seawater / microbiology
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Spectrometry, Mass, Electrospray Ionization
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Water Microbiology
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Antifungal Agents
Supplementary concepts
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Saccharothrix xinjiangensis