Damage Control in the Developing Brain: Tradeoffs and Consequences

Fernando C Alsina; Debra L Silver

doi:10.1016/j.tins.2019.08.004

Damage Control in the Developing Brain: Tradeoffs and Consequences

Trends Neurosci. 2019 Oct;42(10):661-663. doi: 10.1016/j.tins.2019.08.004. Epub 2019 Aug 22.

Authors

Fernando C Alsina¹, Debra L Silver²

Affiliations

¹ Department of Molecular Genetics and Molecular Biology, Duke University Medical Center, Durham, NC, USA.
² Department of Molecular Genetics and Molecular Biology, Duke University Medical Center, Durham, NC, USA; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA; Duke Institute for Brain Science, Duke University Medical Center, Durham, NC, USA. Electronic address: debra.silver@duke.edu.

PMID: 31447171
DOI: 10.1016/j.tins.2019.08.004

Abstract

Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these questions and examines the consequences of both inducing genomic instability and suppressing safeguard mechanisms for the development of the cerebral cortex.

Keywords: aneuploidy; genome stability; microcephaly.

Publication types

Comment

MeSH terms

Aneuploidy*
Brain
Genomic Instability*
Humans