Mind the Gap: Statin Underutilization and Impact on Mortality in Liver Transplant Recipients

Liver Transpl. 2019 Oct;25(10):1477-1479. doi: 10.1002/lt.25627.

Abstract

Liver transplant (LT) recipients are at a substantially increased risk of cardiovascular disease compared due to accelerated development and progression of hypertension, diabetes, obesity and dyslipidemia. As a result, cardiovascular disease is a leading cause of morbidity and mortality post-LT. This is in spite of aggressive pre-transplant evaluation for prevalent cardiovascular disease, in particular coronary artery disease (CAD), and exclusion of very high-risk patients from LT. However the commonest causes of early (<1 year) cardiovascular disease complications are arrhythmias and heart failure, whereas coronary heart disease complications typically manifest later after LT.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Coronary Artery Disease*
  • Graft Rejection
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors*
  • Kidney Transplantation*
  • Liver Transplantation*

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors