Genetic Variation Underpinning ADHD Risk in a Caribbean Community

Cells. 2019 Aug 16;8(8):907. doi: 10.3390/cells8080907.

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 × 10-4), rs2282794-FGF1 (A allele; p = 1.33 × 10-2), rs2122642-ADGRL3 (C allele, p = 3.5 × 10-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.

Keywords: ADGRL3; ADHD; Caribbean community; FBAT; FGF1; LPHN3; SNAP25; genetics; predictive genomics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Attention Deficit Disorder with Hyperactivity / genetics*
  • Black or African American / genetics
  • Case-Control Studies
  • Child
  • Colombia
  • Female
  • Fibroblast Growth Factor 1 / genetics
  • Genetic Predisposition to Disease
  • Haplotypes / genetics*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, Peptide / genetics
  • Synaptosomal-Associated Protein 25 / genetics

Substances

  • ADGRL3 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Peptide
  • SNAP25 protein, human
  • Synaptosomal-Associated Protein 25
  • Fibroblast Growth Factor 1