Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin-epidermal growth factor receptor signaling

J Allergy Clin Immunol. 2019 Dec;144(6):1719-1722.e3. doi: 10.1016/j.jaci.2019.07.041. Epub 2019 Aug 16.

Authors

Andrea Scheffschick¹, Dimitra Kiritsi², Thomas M Magin³

Affiliations

¹ Institute of Biology, Leipzig University, Leipzig, Germany.
² Department of Dermatology, Medical Faculty, Medical Center-University of Freiburg, Freiburg, Germany.
³ Institute of Biology, Leipzig University, Leipzig, Germany. Electronic address: thomas.magin@uni-leipzig.de.

PMID: 31425777
DOI: 10.1016/j.jaci.2019.07.041

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amphiregulin / genetics
Amphiregulin / immunology*
Animals
Cytokines
ErbB Receptors / genetics
ErbB Receptors / immunology*
Humans
Keratins / genetics
Keratins / immunology*
Mice
Mice, Knockout
Pruritus / genetics
Pruritus / immunology*
Pruritus / pathology
Signal Transduction / genetics
Signal Transduction / immunology*
Thymic Stromal Lymphopoietin

Substances

Amphiregulin
Areg protein, mouse
Cytokines
Keratins
EGFR protein, mouse
ErbB Receptors
Thymic Stromal Lymphopoietin