Abstract
The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Death / drug effects
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Ions / chemistry
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Metals, Heavy / chemistry*
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Models, Molecular
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Polymers / chemistry*
Substances
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Antineoplastic Agents
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Ions
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Metals, Heavy
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Organometallic Compounds
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Polymers