Rethinking the PDH Bypass and GABA Shunt as Thiamin-Deficiency Workarounds

Plant Physiol. 2019 Oct;181(2):389-393. doi: 10.1104/pp.19.00857. Epub 2019 Aug 13.

Authors

Jaya Joshi¹, Jacob S Folz², Jesse F Gregory 3rd³, Donald R McCarty¹, Oliver Fiehn², Andrew D Hanson⁴

Affiliations

¹ Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611.
² West Coast Metabolomics Center, University of California Davis, Davis, California 95616.
³ Department of Food Science and Human Nutrition, University of Florida, Gainesville, Florida 32611.
⁴ Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611 adha@ufl.edu.

Abstract

The PDH bypass and the GABA shunt serve to maintain mainline metabolic fluxes during episodes of organellar thiamin diphosphate deficiency.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Plants / metabolism*
Pyruvate Decarboxylase / metabolism*
Thiamine Pyrophosphate / metabolism*
gamma-Aminobutyric Acid / metabolism*

Substances

gamma-Aminobutyric Acid
Pyruvate Decarboxylase
Thiamine Pyrophosphate