Cobalt-Catalyzed α-Arylation of Substituted α-Halogeno β-Lactams

Vanessa Koch; Mélanie M Lorion; Etienne Barde; Stefan Bräse; Janine Cossy

doi:10.1021/acs.orglett.9b02122

Cobalt-Catalyzed α-Arylation of Substituted α-Halogeno β-Lactams

Org Lett. 2019 Aug 16;21(16):6241-6244. doi: 10.1021/acs.orglett.9b02122. Epub 2019 Aug 7.

Authors

Vanessa Koch^{1

2}, Mélanie M Lorion¹, Etienne Barde¹, Stefan Bräse^{2

3}, Janine Cossy¹

Affiliations

¹ Molecular, Macromolecular Chemistry and Materials (C3M) , ESPCI Paris , CNRS, PSL University, 10 rue Vauquelin , 75231 Paris Cedex 05, France.
² Institute for Organic Chemistry (IOC) , Karlsruhe Institute for Technology (KIT) , Fritz-Haber-Weg 6 , 76131 Karlsruhe , Germany.
³ Institute for Toxicology and Genetics (ITG) , Hermann-von-Helmholtz Platz 1 , 76344 Eggenstein-Leopoldshafen , Germany.

PMID: 31390216
DOI: 10.1021/acs.orglett.9b02122

Abstract

The treatment of 3-bromo β-lactams by an aryl Grignard, in the presence of CoCl₂ (2 mol %) and TMEDA (2 mol %) in THF, produces 3-aryl β-lactams in good yields and excellent diastereoselectivity.

Publication types

Research Support, Non-U.S. Gov't