Radiation effective dose assessment of [51Mn]- and [52Mn]-chloride

Laura De Nardo; Guillermina Ferro-Flores; Cristina Bolzati; Juan Esposito; Laura Meléndez-Alafort

doi:10.1016/j.apradiso.2019.108805

Radiation effective dose assessment of [⁵¹Mn]- and [⁵²Mn]-chloride

Appl Radiat Isot. 2019 Nov:153:108805. doi: 10.1016/j.apradiso.2019.108805. Epub 2019 Jul 11.

Authors

Laura De Nardo¹, Guillermina Ferro-Flores², Cristina Bolzati³, Juan Esposito⁴, Laura Meléndez-Alafort⁵

Affiliations

¹ Department of Physics and Astronomy, University of Padova, Via Marzolo 8, Padova, 35131, Italy; INFN, Sezione di Padova, Via Marzolo 8, Padova, 35131, Italy. Electronic address: laura.denardo@unipd.it.
² Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos-CONACyT, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, 52750, Mexico. Electronic address: guillermina.ferro@inin.gob.mx.
³ Istituto di Chimica della Materia Condensata e di Tecnologie per l'Energia (ICMATE), Consiglio Nazionale delle Ricerche, Corso Stati Uniti, 4, Padova, 35100, Italy. Electronic address: cristina.bolzati@cnr.it.
⁴ Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell'Università, 2, Legnaro, 35020, Italy. Electronic address: juan.esposito@lnl.infn.it.
⁵ Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padova, 35128, Italy. Electronic address: laura.melendezalafort@iov.veneto.it.

PMID: 31382087
DOI: 10.1016/j.apradiso.2019.108805

Abstract

In order to establish the potential of [^51/52Mn]Cl₂ as safe PET brain tracers, the radiation effective dose (ED) of [⁵¹Mn]- and [⁵²Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [⁵²Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [⁵¹Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of ⁵²Mn allows a PET image resolution similar to that of ¹⁸F, activities below 15 MBq should be administered.

Keywords: Mn-51 dosimetry; Mn-52 dosimetry; PET brain tracers; [(51/52)Mn]Cl(2) effective dose.