Recent advances in ruthenium and platinum based supramolecular coordination complexes for antitumor therapy

Xiaoming Zhang; Dapeng Liu; Fangyuan Lv; Bing Yu; Youqing Shen; Hailin Cong

doi:10.1016/j.colsurfb.2019.110373

Recent advances in ruthenium and platinum based supramolecular coordination complexes for antitumor therapy

Colloids Surf B Biointerfaces. 2019 Oct 1:182:110373. doi: 10.1016/j.colsurfb.2019.110373. Epub 2019 Jul 26.

Authors

Xiaoming Zhang¹, Dapeng Liu¹, Fangyuan Lv¹, Bing Yu², Youqing Shen³, Hailin Cong⁴

Affiliations

¹ Institute of Biomedical Materials and Engineering, College of Materials Sciences and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, China.
² Institute of Biomedical Materials and Engineering, College of Materials Sciences and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 266071, China.
³ Institute of Biomedical Materials and Engineering, College of Materials Sciences and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
⁴ Institute of Biomedical Materials and Engineering, College of Materials Sciences and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 266071, China. Electronic address: conghailin@qdu.edu.cn.

PMID: 31376689
DOI: 10.1016/j.colsurfb.2019.110373

Abstract

Since the discovery of cisplatin for antitumor activity, the platinum (Pt) based antitumor drugs have received significant attention and launched a new era to explore the transition metal complexes for therapy. However, these small Pt-based antitumor drugs have some limitations for their clinic application, such as short blood circulation time and limited accumulation at tumor site, which was mainly due to their poor water solubility and small molecule size. To overcome these obstacles, developing new generation of transition-metal based complexes as anticancer agents is urgently needed. For the unique properties, the ruthenium (Ru) based complexes have attractive significant attention and be expected to be a substitute for Pt-based anticancer agents. Due to the nanometer size, unique geometry, relatively high surface charge and unique photophysical properties, the transition-metal based supramolecular coordination complexes (SCCs) which exhibited excellent antitumor efficiency and possessed desirable bioapplications such as drug loading, bioimaging and biosensing have attracted great attention as anticancer agents. In this minireview, we will highlight the recent development of ruthenium (Ru) and Platinum (Pt) based SCCs as potential anticancer agents.

Keywords: Anticancer therapy; Metal coordination complexes; Supramolecular coordination complexes.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Coordination Complexes / chemistry*
Coordination Complexes / pharmacology
Humans
Mice
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / pathology
Platinum / chemistry*
Ruthenium / chemistry*
Xenograft Model Antitumor Assays*

Substances

Antineoplastic Agents
Coordination Complexes
Platinum
Ruthenium