Metabolic interventions in Autism Spectrum Disorder

Susanna B Mierau; Ann M Neumeyer

doi:10.1016/j.nbd.2019.104544

Metabolic interventions in Autism Spectrum Disorder

Neurobiol Dis. 2019 Dec:132:104544. doi: 10.1016/j.nbd.2019.104544. Epub 2019 Jul 24.

Authors

Susanna B Mierau¹, Ann M Neumeyer²

Affiliations

¹ Dept. of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Electronic address: sbm33@cam.ac.uk.
² Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA; Harvard Medical School, Boston, MA USA. Electronic address: ANEUMEYER@mgh.harvard.edu.

PMID: 31351171
DOI: 10.1016/j.nbd.2019.104544

Abstract

Metabolic interventions including special diets and supplements are commonly used in Autism Spectrum Disorder (ASD). Yet little is known about how these interventions, typically initiated by caregivers, may affect metabolic function or the core symptoms of ASD. This review examines possible direct and indirect roles for metabolism in the core symptoms of ASD as well as evidence for metabolic dysfunction and nutritional deficiencies. We also discuss some of the most popular diets and supplements used in our patient population and suggest strategies for discussing the utility of these interventions with patients, families, and caregivers.

Publication types

Review

MeSH terms

Autism Spectrum Disorder / diet therapy*
Autism Spectrum Disorder / epidemiology
Autism Spectrum Disorder / metabolism*
Diet, Gluten-Free / methods
Diet, Gluten-Free / trends
Diet, Ketogenic / methods
Diet, Ketogenic / trends
Dietary Supplements
Humans
Metabolic Diseases / diet therapy
Metabolic Diseases / epidemiology
Metabolic Diseases / metabolism
Nutritional Status / physiology*
Nutritional Support / methods*
Nutritional Support / trends
Vitamins / administration & dosage

Substances

Vitamins