Measurements of Duodenal Mucosal Integrity Are Altered in Celiac Disease

Dawn W Adams; Dhyanesh Patel; Lauren Evers; James C Slaughter; Tina Higginbotham; Michael Vaezi

doi:10.1016/j.cgh.2019.07.032

Measurements of Duodenal Mucosal Integrity Are Altered in Celiac Disease

Clin Gastroenterol Hepatol. 2020 Jun;18(7):1641-1642. doi: 10.1016/j.cgh.2019.07.032. Epub 2019 Jul 24.

Authors

Dawn W Adams¹, Dhyanesh Patel², Lauren Evers³, James C Slaughter⁴, Tina Higginbotham², Michael Vaezi²

Affiliations

¹ Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: dawn.w.adams@vumc.org.
² Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

PMID: 31351133
DOI: 10.1016/j.cgh.2019.07.032

Abstract

Altered barrier function is a part of celiac disease (CeD) pathophysiology that we currently cannot reliably measure. Catheter-based mucosal integrity (MI) is an endoscopic technology that has identified altered esophageal barrier function in esophageal disease.¹ The aim of this study was to evaluate feasibility, safety, and clinical utility of measuring duodenal integrity with an MI catheter in patients with and without CeD.

MeSH terms

Celiac Disease* / diagnosis
Duodenum
Humans
Intestinal Mucosa