Hedgehog signaling promotes TH2 differentiation in naive human CD4 T cells

J Allergy Clin Immunol. 2019 Nov;144(5):1419-1423.e1. doi: 10.1016/j.jaci.2019.07.011. Epub 2019 Jul 24.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzimidazoles / pharmacology
  • CD4-Positive T-Lymphocytes / physiology*
  • Cell Differentiation
  • Cells, Cultured
  • Cytokines / metabolism
  • Gene Expression Regulation
  • Hedgehog Proteins / antagonists & inhibitors
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / metabolism*
  • Humans
  • Lymphocyte Activation
  • Phenylurea Compounds / pharmacology
  • Signal Transduction
  • Th2 Cells / physiology*
  • Zinc Finger Protein Gli2 / metabolism*

Substances

  • Benzimidazoles
  • Cytokines
  • Hedgehog Proteins
  • Phenylurea Compounds
  • Zinc Finger Protein Gli2
  • glasdegib