Clinical and pathologic analysis of myopericytoma in the oral and maxillofacial region

Wu-Tong Ju; Tong-Chao Zhao; Ying Liu; Min-Jun Dong; Li-Zhen Wang; Jiang Li; Yi-Ran Tan; Lai-Ping Zhong

doi:10.1016/j.oooo.2019.06.004

Clinical and pathologic analysis of myopericytoma in the oral and maxillofacial region

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Oct;128(4):393-399. doi: 10.1016/j.oooo.2019.06.004. Epub 2019 Jun 14.

Authors

Wu-Tong Ju¹, Tong-Chao Zhao¹, Ying Liu¹, Min-Jun Dong², Li-Zhen Wang³, Jiang Li⁴, Yi-Ran Tan⁵, Lai-Ping Zhong¹

Affiliations

¹ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
² Department of Radiology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
³ Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: Wanglizhen9th@hotmail.com.
⁴ Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
⁵ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: 116185@sh9hospital.org.

PMID: 31350225
DOI: 10.1016/j.oooo.2019.06.004

Abstract

Objective: The aim of this study was to analyze myopericytoma in the oral and maxillofacial region in terms of clinical appearance, diagnosis, treatment, and outcomes.

Study design: Data on 5 new patients with myopericytoma in the oral and maxillofacial region treated at our department were collected and analyzed.

Results: There were 2 males and 3 females (age range 10-62 years; mean age 43.8 years). All of the 5 patients presented with masses showing benign biologic behavior. Imaging examinations with use of computed tomography or magnetic resonance imaging showed heterogeneous regions with internal contrast-enhancement or cystic change in 3 cases. All of the patients underwent surgery. Histologic examination showed a broad morphologic spectrum characterized by concentric and perivascular growth of ovoid, plump spindled, and/or round myoid tumor cells. Immunohistochemical examination showed positive staining for vimentin and smooth muscle actin, and negative for CD34 and desmin. During the follow-up period (8-56 months), there was no tumor recurrence.

Conclusions: Myopericytoma in the oral and maxillofacial region always exhibits benign biologic behavior and a heterogeneous region with internal contrast-enhancement or cystic change on imaging examinations. Surgery is the first choice of treatment and results in good clinical outcomes.

MeSH terms

Adolescent
Adult
Child
Desmin
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mouth Neoplasms* / diagnosis
Mouth Neoplasms* / therapy
Myopericytoma* / diagnosis
Myopericytoma* / therapy
Neoplasm Recurrence, Local
Young Adult

Substances

Desmin