The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice

DNA Repair (Amst). 2019 Sep:81:102662. doi: 10.1016/j.dnarep.2019.102662. Epub 2019 Jul 8.

Abstract

DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process.

Keywords: DNA double strand break repair; Homologous recombination; NHEJ; R-loops; RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism*
  • DNA Breaks, Double-Stranded*
  • DNA End-Joining Repair
  • DNA Repair*
  • Eukaryota / genetics
  • Eukaryota / metabolism
  • Humans
  • Nucleic Acid Hybridization
  • RNA / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Recombinational DNA Repair

Substances

  • RNA-Binding Proteins
  • RNA
  • DNA