A Novel Non-invasive Method for Predicting Liver Fibrosis by Quantifying the Hepatic Vein Waveform

Yoko Soroida; Takuma Nakatsuka; Masaya Sato; Hayato Nakagawa; Mariko Tanaka; Naoko Yamauchi; Taijiro Wake; Ryo Nakagomi; Mizuki Nishibatake Kinoshita; Tatsuya Minami; Koji Uchino; Kenichiro Enooku; Yoshinari Asaoka; Yasuo Tanaka; Momoe Endo; Ayaka Nakamura; Tamaki Kobayashi; Makiko Kurihara; Hiromi Hikita; Mamiko Sato; Hiroaki Gotoh; Tomomi Iwai; Masashi Fukayama; Hitoshi Ikeda; Ryosuke Tateishi; Yutaka Yatomi; Kazuhiko Koike

doi:10.1016/j.ultrasmedbio.2019.05.028

A Novel Non-invasive Method for Predicting Liver Fibrosis by Quantifying the Hepatic Vein Waveform

Ultrasound Med Biol. 2019 Sep;45(9):2363-2371. doi: 10.1016/j.ultrasmedbio.2019.05.028. Epub 2019 Jul 12.

Authors

Yoko Soroida¹, Takuma Nakatsuka², Masaya Sato³, Hayato Nakagawa⁴, Mariko Tanaka⁵, Naoko Yamauchi⁵, Taijiro Wake², Ryo Nakagomi², Mizuki Nishibatake Kinoshita², Tatsuya Minami², Koji Uchino², Kenichiro Enooku², Yoshinari Asaoka², Yasuo Tanaka², Momoe Endo¹, Ayaka Nakamura¹, Tamaki Kobayashi¹, Makiko Kurihara¹, Hiromi Hikita¹, Mamiko Sato¹, Hiroaki Gotoh¹, Tomomi Iwai¹, Masashi Fukayama⁵, Hitoshi Ikeda¹, Ryosuke Tateishi², Yutaka Yatomi¹, Kazuhiko Koike²

Affiliations

¹ Department of Clinical Laboratory, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
² Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
³ Department of Clinical Laboratory, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
⁴ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: hanakagawa-tky@umin.ac.jp.
⁵ Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

PMID: 31303401
DOI: 10.1016/j.ultrasmedbio.2019.05.028

Abstract

The hepatic vein (HV) waveform by Doppler ultrasound reflects the severity of liver fibrosis. We conducted a proof-of-concept study of a new method for quantifying the HV waveform. We calculated the coefficient of variation (CV) of the HV flow velocity and created a new index "q-HV" (quantified HV) and analyzed its performance for predicting histologic liver fibrosis in 114 patients with chronic liver disease. The CV of the HV flow velocity was well associated with flattening of the waveform and the q-HV significantly increased with the progression of liver fibrosis. The areas under the curve for the prediction of fibrosis stage were 0.732 for F2, 0.772 for F3 and 0.805 for F4. Combined q-HV and FIB-4 index (widely used liver fibrosis score) increased the diagnostic accuracy for liver fibrosis. The q-HV showed good accuracy for predicting liver fibrosis; thus, q-HV is feasible and acceptable as a non-invasive tool for predicting liver fibrosis.

Keywords: Doppler; Hepatic vein waveform; Liver fibrosis; Ultrasonography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biopsy
Disease Progression
Female
Hepatic Veins / diagnostic imaging*
Humans
Liver Cirrhosis / diagnostic imaging*
Liver Function Tests
Male
Middle Aged
Predictive Value of Tests
Proof of Concept Study
Prospective Studies
Severity of Illness Index
Ultrasonography, Doppler / methods*