Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum

Pediatr Obes. 2019 Nov;14(11):e12560. doi: 10.1111/ijpo.12560. Epub 2019 Jul 11.

Abstract

Background: It is unknown to what extent higher maternal blood pressure (BP) in early postpartum impacts the relationship between higher maternal weight status and greater infant weight gain in early postpartum.

Objective: To evaluate the mediating role of higher maternal BP at 1 month postpartum on the association between higher maternal weight status at 1 month postpartum and greater infant weight gain over 6 months postpartum.

Methods: Participants were 169 Hispanic mother-infant pairs. Maternal body mass index (BMI) and BP were assessed at 1 month postpartum. Infant weight was measured at 1 and 6 months postpartum to calculate weight-for-age z scores (WAZ). Multiple linear regression models were used for prediction, and Sobel test was used to determine mediation.

Results: Controlling for maternal pre-pregnancy BMI, age, delivery mode, infant sex, and infant birth weight revealed that both maternal BMI (β = .29) and BP (β = .32) predicted infant WAZ gain (both P ≤ .03). However, the relationship between infant WAZ gain and maternal BMI was no longer significant after further adjustment for maternal BP, which remained significant (P < .05). Maternal BP explained 23.6% (Sobel T = 2.01) of the association between maternal BMI at 1 month and infant WAZ gain over 6 months.

Conclusion: Our data suggest that higher maternal weight status at 1 month postpartum is related to greater infant weight gain over 6 months postpartum, and this relationship is mediated by higher maternal BP at 1 month postpartum.

Keywords: blood pressure; infant; mother; obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Birth Weight
  • Blood Pressure / physiology*
  • Body Mass Index
  • Female
  • Hispanic or Latino / statistics & numerical data
  • Humans
  • Infant
  • Linear Models
  • Los Angeles
  • Male
  • Mothers*
  • Multivariate Analysis
  • Obesity, Maternal / physiopathology*
  • Postpartum Period / physiology
  • Pregnancy
  • Weight Gain / physiology*