M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge

Cancer Cell. 2019 Jul 8;36(1):3-5. doi: 10.1016/j.ccell.2019.06.004.

Abstract

In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Dancing*
  • Enzyme Inhibitors
  • Humans
  • Methylation
  • Neoplasms*
  • Protein-Arginine N-Methyltransferases
  • Repressor Proteins

Substances

  • Enzyme Inhibitors
  • Repressor Proteins
  • PRMT1 protein, human
  • PRMT5 protein, human
  • Protein-Arginine N-Methyltransferases

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