Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency

Br J Haematol. 2019 Sep;186(6):e198-e201. doi: 10.1111/bjh.16077. Epub 2019 Jul 8.

Grace Egan¹, Fred G Pluthero², Vanessa Bouskill³, Pamela Hilliard⁴, Luke J Drury⁵, Manuel D Carcao^{1

4}, Walter H A Kahr^{1

2

6}

¹ Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
² Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
³ Department of Nursing, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ Child Health Evaluative Sciences Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
⁵ Prevention Genetics, Marshfield, WI, USA.
⁶ Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

No abstract available

Keywords: SERPINF2; alpha-2-antiplasmin; bleeding disorder; fibrinolytic abnormality.

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