Improved assessment of mass drug administration and health district management performance to eliminate lymphatic filariasis

PLoS Negl Trop Dis. 2019 Jul 5;13(7):e0007337. doi: 10.1371/journal.pntd.0007337. eCollection 2019 Jul.

Abstract

Lymphatic filariasis (LF) elimination as a public health problem requires the interruption of transmission by administration of preventive mass drug administration (MDA) to the eligible population living in endemic districts. Suboptimal MDA coverage leads to persistent parasite transmission with consequential infection, disease and disability, and the need for continuing MDA rounds, requiring considerable investment. Routine coverage reports must be verified in each MDA implementation unit (IU) due to incorrect denominators and numerators used to calculate coverage estimates with administrative data. IU are usually the health districts. Coverage is verified so IU teams can evaluate their outreach and take appropriate action to improve performance. Mozambique and the Democratic Republic of Congo (DRC) have conducted MDA campaigns for LF since 2009 and 2014, respectively. To verify district reports and assess the declared achievement using administrative data of the minimum 80% coverage of eligible people (or 65% of the total population), both countries conducted rapid probability surveys using Lot Quality Assurance Sampling (LQAS)(n = 1102) in 2015 and 2016 in 58 IU in 49 districts. The surveys identified IU with suboptimal coverage, reasons residents did not take the medication, place where the medication was received, information sources, and knowledge about diseases prevented by the MDA. LQAS identified four inadequately covered IU triggering district team performance reviews with provincial and national teams and district retreatment. Provincial estimates using probability samples (weighted by populations sizes) were 10 and 17 percentage points lower than reported coverage in DRC and Mozambique. The surveys identified: absence from home during annual MDA rounds as the main reason for low performance and provided valuable information about pre-campaign and campaign activities resulting in improved strategies and continued progress towards elimination of LF and co-endemic Neglected Tropical Diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Democratic Republic of the Congo / epidemiology
  • Disease Eradication / methods
  • Disease Eradication / standards*
  • Elephantiasis, Filarial / prevention & control*
  • Endemic Diseases / prevention & control
  • Filaricides / administration & dosage*
  • Humans
  • Mass Drug Administration / standards*
  • Mozambique / epidemiology
  • Neglected Diseases / epidemiology
  • Neglected Diseases / prevention & control
  • Outcome and Process Assessment, Health Care*
  • Public Health
  • Quality Assurance, Health Care*
  • Wuchereria bancrofti / drug effects

Substances

  • Filaricides

Grants and funding

CMC, PHP, NW, LS, MM, DW, CJ were funded by the following grant by the UK Department for International Development (DFID) to support the LF Elimination Programme (LF) 2009-2017. https://www.gov.uk/government/organisations/department-for-international-development The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.