Interactions between pain states and opioid reward assessed with intracranial self-stimulation in rats

Abstract

Opioids are an essential component of current clinical treatments for pain, but they also produce side effects that include abuse liability. Recent media attention surrounding the use of opioids in the United States has elevated the discussion of their benefits and drawbacks to one of national concern, leading to increased scrutiny of prescribing practices. Regulatory agencies have responded by recommending stricter limits on the amount and duration of opioid prescriptions for pain treatment; however, the relationship between pain states and the abuse-related effects of opioids is still not completely understood. Intracranial self-stimulation (ICSS) is one preclinical procedure that can be used to study the abuse-related effects of opioids in naïve subjects over the course of initial opioid exposure and in the context of inferred pain states. The goal of this review is to provide a summary of evidence from our laboratory using ICSS to study the modulation of opioid reward by pain states and examine these results in the context of related studies from other groups. This article is part of the Special Issue entitled 'New Vistas in Opioid Pharmacology'.

Keywords: Antinociception; Intracranial self-stimulation; Mu opioid receptor.