Progress update from the hippocampal subfields group

Rosanna K Olsen; Valerie A Carr; Ana M Daugherty; Renaud La Joie; Robert S C Amaral; Katrin Amunts; Jean C Augustinack; Arnold Bakker; Andrew R Bender; David Berron; Marina Boccardi; Martina Bocchetta; Alison C Burggren; M Mallar Chakravarty; Gaël Chételat; Robin de Flores; Jordan DeKraker; Song-Lin Ding; Mirjam I Geerlings; Yushan Huang; Ricardo Insausti; Elliott G Johnson; Prabesh Kanel; Olga Kedo; Kristen M Kennedy; Attila Keresztes; Joshua K Lee; Ulman Lindenberger; Susanne G Mueller; Elizabeth M Mulligan; Noa Ofen; Daniela J Palombo; Lorenzo Pasquini; John Pluta; Naftali Raz; Karen M Rodrigue; Margaret L Schlichting; Yee Lee Shing; Craig E L Stark; Trevor A Steve; Nanthia A Suthana; Lei Wang; Markus Werkle-Bergner; Paul A Yushkevich; Qijing Yu; Laura E M Wisse; Hippocampal Subfields Group

doi:10.1016/j.dadm.2019.04.001

Progress update from the hippocampal subfields group

Alzheimers Dement (Amst). 2019 Jun 13:11:439-449. doi: 10.1016/j.dadm.2019.04.001. eCollection 2019 Dec.

Authors

Rosanna K Olsen^{1

2}, Valerie A Carr³, Ana M Daugherty^{4

5

6}, Renaud La Joie⁷, Robert S C Amaral⁸, Katrin Amunts^{9

10

11}, Jean C Augustinack^{12

13}, Arnold Bakker¹⁴, Andrew R Bender^{15

16

17}, David Berron^{18

19}, Marina Boccardi^{20

21}, Martina Bocchetta²², Alison C Burggren²³, M Mallar Chakravarty^{8

24

25}, Gaël Chételat^{26

27

28}, Robin de Flores^{26

27}, Jordan DeKraker²⁹, Song-Lin Ding³⁰, Mirjam I Geerlings^{31

32}, Yushan Huang³³, Ricardo Insausti³⁴, Elliott G Johnson³⁵, Prabesh Kanel³⁶, Olga Kedo¹⁰, Kristen M Kennedy³⁷, Attila Keresztes^{38

39}, Joshua K Lee^{40

35}, Ulman Lindenberger^{39

41}, Susanne G Mueller⁴², Elizabeth M Mulligan⁴³, Noa Ofen^{4

6

44}, Daniela J Palombo⁴⁵, Lorenzo Pasquini⁷, John Pluta⁴⁶, Naftali Raz^{4

6

38}, Karen M Rodrigue³⁷, Margaret L Schlichting², Yee Lee Shing^{38

47}, Craig E L Stark⁴⁸, Trevor A Steve⁴⁹, Nanthia A Suthana⁵⁰, Lei Wang⁵¹, Markus Werkle-Bergner³⁸, Paul A Yushkevich⁵², Qijing Yu^{4

6}, Laura E M Wisse^{52

53}; Hippocampal Subfields Group

Affiliations

¹ Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
² Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
³ Department of Psychology, San Jose State University, San Jose, CA, USA.
⁴ Department of Psychology, Wayne State University, Detroit, MI, USA.
⁵ Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
⁶ Institute of Gerontology, Wayne State University, Detroit, MI, USA.
⁷ Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
⁸ Cerebral Imaging Centre, Douglas Hospital Mental Health University Institute, Verdun, Quebec, Canada.
⁹ C. and O. Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.
¹⁰ Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
¹¹ Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
¹² Department of Radiology, Harvard Medical School, Charlestown, MA, USA.
¹³ Massachusetts General Hospital, Charlestown, MA, USA.
¹⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁵ Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
¹⁶ Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI, USA.
¹⁷ College of Human Medicine, Michigan State University, East Lansing, MI, USA.
¹⁸ Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
¹⁹ German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
²⁰ Department of Psychiatry, University of Geneva, Geneva, Switzerland.
²¹ IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
²² Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, United Kingdom.
²³ Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA.
²⁴ Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
²⁵ Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada.
²⁶ Université Normandie, Université de Caen-Normandie, Caen, France.
²⁷ Institut National de la Santé et de la Recherché Médicale (INSERM), UMR-S U1237, Caen, France.
²⁸ GIP Cyceron, Caen, France.
²⁹ Robarts Research Institute, Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada.
³⁰ Allen Institute for Brain Science, Seattle, WA, USA.
³¹ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³² Utrecht University, Utrecht, The Netherlands.
³³ Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
³⁴ Human Neuroanatomy Laboratory, University of Castilla-La Mancha, Albacete, Spain.
³⁵ Center for Mind and Brain, University of California, Davis, CA, USA.
³⁶ Department of Radiology at the University of Michigan, Ann Arbor, MI, USA.
³⁷ Center for Vital Longevity, Behavioral and Brain Science, The University of Texas at Dallas, Dallas, TX, USA.
³⁸ Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
³⁹ Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
⁴⁰ Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Davis, CA, USA.
⁴¹ Max Planck - University College London Centre for Computational Psychiatry and Ageing Research, Berlin, Germany and London, United Kingdom.
⁴² Department of Radiology, University of California, San Francisco, CA, USA.
⁴³ Department of Psychology, Florida State University, Tallahassee, FL, USA.
⁴⁴ Neurobiology Department, Weizmann Institute of Science, Rehovot, Israel.
⁴⁵ Department of Psychology, University of British Columbia, Vancouver, British Colombia, Canada.
⁴⁶ Division of Translational Medicine and Genomics, University of Pennsylvania, Philadelphia, PA, USA.
⁴⁷ Institute of Psychology, Goethe University Frankfurt, Frankfurt, Germany.
⁴⁸ Department of Neurobiology and Behavior, Center for Learning and Memory, University of California, Irvine, CA, USA.
⁴⁹ Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
⁵⁰ Department of Psychiatry and Biobehavioral Sciences, Department of Neurosurgery, University of California, Los Angeles, CA, USA.
⁵¹ Department of Psychiatry and Behavioral Sciences and Department Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁵² Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
⁵³ Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence.

Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption.

Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures.

Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Keywords: Cytoarchitecture; Hippocampus; Histology; Human; Neuroanatomy; Neuroimaging; Structural imaging; Volumetry; ex vivo.

Abstract

Grants and funding