Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain

Sravani Polepalli; Sophia M George; R Valli Sri Vidya; Gabriel Sunil Rodrigues; L Ramachandra; Raghu Chandrashekar; Deepak Nayak M; Praveen P N Rao; Richard G Pestell; Mahadev Rao

doi:10.1016/j.biocel.2019.06.006

Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain

Int J Biochem Cell Biol. 2019 Sep:114:105558. doi: 10.1016/j.biocel.2019.06.006. Epub 2019 Jun 22.

Authors

Affiliations

¹ Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: sravani.polepalli2894@gmail.com.
² Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: sophiamgeorge.108@gmail.com.
³ Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: vallisrividyar@gmail.com.
⁴ Department of General Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: gaby.rodrigues@manipal.edu.
⁵ Department of General Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: ramachandra.l@manipal.edu.
⁶ Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: raghu.c@manipal.edu.
⁷ Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: deepak.nayak@manipal.edu.
⁸ School of Pharmacy, Health Sciences Campus, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. Electronic address: praoperampallinekkar@uwaterloo.ca.
⁹ Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, Wynnewood, Pennsylvania, 19096; Chief Medical Officer, CytoDyn Inc, 111 Main St, Suite 660, Vancouver, WA, 98660, USA. Electronic address: richard.pestell@gmail.com.
¹⁰ Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address: mahadev.rao@manipal.edu.

PMID: 31238111
DOI: 10.1016/j.biocel.2019.06.006

Abstract

The figure describes the location of UHRF1 (Ubiquitin-like with containing PHD and RING Finger domains 1) gene, mRNA and protein synthesis in the tumor cell and its structural domains with a focus on the docking of Naphthazarin on the SRA domain of UHRF1, resulting in reduction of tumor size.

Keywords: Cancer; SRA domain; UHRF1; Universal oncogene.

Publication types

Review

MeSH terms

Animals
CCAAT-Enhancer-Binding Proteins* / chemistry
CCAAT-Enhancer-Binding Proteins* / genetics
CCAAT-Enhancer-Binding Proteins* / metabolism
Humans
Molecular Docking Simulation*
Neoplasm Proteins* / chemistry
Neoplasm Proteins* / genetics
Neoplasm Proteins* / metabolism
Neoplasms* / genetics
Neoplasms* / metabolism
Neoplasms* / pathology
Neoplasms* / therapy
Protein Domains
Ubiquitin-Protein Ligases* / chemistry
Ubiquitin-Protein Ligases* / genetics
Ubiquitin-Protein Ligases* / metabolism

Substances

CCAAT-Enhancer-Binding Proteins
Neoplasm Proteins
UHRF1 protein, human
Ubiquitin-Protein Ligases