Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery; Richard W Birkinshaw; Tamia Nguyen; Jia-Nan Gong; Ella R Thompson; Zhen Xu; David A Westerman; Peter E Czabotar; Michael Dickinson; David C S Huang; John F Seymour; Andrew W Roberts

doi:10.1111/bjh.16069

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Br J Haematol. 2019 Sep;186(6):e188-e191. doi: 10.1111/bjh.16069. Epub 2019 Jun 24.

Authors

Piers Blombery^{1

2

3}, Richard W Birkinshaw^{4

5}, Tamia Nguyen^{1

3}, Jia-Nan Gong^{4

5}, Ella R Thompson^{1

3}, Zhen Xu^{4

5}, David A Westerman^{1

2

3}, Peter E Czabotar^{4

5}, Michael Dickinson^{2

3}, David C S Huang^{4

5}, John F Seymour^{2

3}, Andrew W Roberts^{2

4

5

6

7}

Affiliations

¹ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.
² Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
³ Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
⁵ Department of Medical Biology, University of Melbourne, Melbourne, Australia.
⁶ Centre for Cancer Research, University of Melbourne, Melbourne, Australia.
⁷ Victorian Comprehensive Cancer Centre, Melbourne, Australia.

PMID: 31234236
DOI: 10.1111/bjh.16069

No abstract available

Keywords: BCL2; genetic analysis; lymphomas.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Substitution
Bridged Bicyclo Compounds, Heterocyclic / administration & dosage*
Drug Resistance, Neoplasm / genetics*
Humans
Lymphoma, Follicular / drug therapy
Lymphoma, Follicular / genetics*
Male
Middle Aged
Mutation, Missense*
Proto-Oncogene Proteins c-bcl-2 / genetics*
Sulfonamides / administration & dosage*

Substances

BCL2 protein, human
Bridged Bicyclo Compounds, Heterocyclic
Proto-Oncogene Proteins c-bcl-2
Sulfonamides
venetoclax