Sleep: DNA Repair Function for Better Neuronal Aging?

Philippe Mourrain; Gordon X Wang

doi:10.1016/j.cub.2019.05.018

Sleep: DNA Repair Function for Better Neuronal Aging?

Curr Biol. 2019 Jun 17;29(12):R585-R588. doi: 10.1016/j.cub.2019.05.018.

Authors

Philippe Mourrain¹, Gordon X Wang²

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305, USA; INSERM 1024, Ecole Normale Supérieure Paris, 75005, France. Electronic address: mourrain@stanford.edu.
² Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305, USA. Electronic address: gordon.wang@stanford.edu.

PMID: 31211981
DOI: 10.1016/j.cub.2019.05.018

Abstract

A novel potential role of sleep is neuronal DNA repair. Live imaging of chromosome dynamics in zebrafish neurons has uncovered how sleep can repair DNA breaks accumulated during wake to maintain genome integrity and likely slow down neuronal aging.

Publication types

Comment

MeSH terms

Animals
Chromosomes
DNA Damage
DNA Repair
Neurons*
Sleep*

Grants and funding

K01 AG061230/AG/NIA NIH HHS/United States