Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model

PLoS One. 2019 Jun 11;14(6):e0216829. doi: 10.1371/journal.pone.0216829. eCollection 2019.

Abstract

This study investigated the effectiveness of new hemostatic adhesive powder (UI-EWD) in a swine mode of acute gastric bleeding. Gastric ulcer bleeding was induced endoscopically at two locations in each of eight heparinized mini-pigs. UI-EWD and saline were sprayed endoscopically in the experimental (n = 5) and control groups (n = 3), respectively. The hemostatic effect and hydrogel persistence on ulcers were periodically evaluated endoscopically. Initial hemostasis was achieved successfully in all lesions in the experimental group. Follow-up endoscopy showed minor delayed bleeding in 10% at 6 hours in the experimental group, whereas re-bleeding was observed in 50% at 6 hours in the control group. UI-EWD gel persisted at 90%, 80%, and 50% of ulcer bases at 6, 18, and 42 hours post-application, respectively. This study suggests that muco-adhesive UI-EWD may be effective in the endoscopic treatment of active ulcer bleeding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Animals
  • Disease Models, Animal
  • Drug Delivery Systems*
  • Endoscopy*
  • Gastric Mucosa / metabolism*
  • Gastrointestinal Hemorrhage / drug therapy*
  • Gastrointestinal Hemorrhage / metabolism
  • Gastrointestinal Hemorrhage / physiopathology*
  • Hemostasis / drug effects
  • Hemostatics / metabolism
  • Hemostatics / pharmacology*
  • Hemostatics / therapeutic use
  • Powders
  • Swine

Substances

  • Hemostatics
  • Powders

Grants and funding

This work was funded by the Korean Ministry of Trade, Industry and Energy (MOTIE) and by the Korea Institute for Advancement of Technology (KIAT) via the International Cooperative R&D program. Utah-Inha DDS provided support in the form of salary for authors EL, JHM, and KK. BMG Incorporated provided support in the form of salary for author BMG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.