Joint High-Order Multi-Task Feature Learning to Predict the Progression of Alzheimer's Disease

Med Image Comput Comput Assist Interv. 2018 Sep:11070:555-562. doi: 10.1007/978-3-030-00928-1_63. Epub 2018 Sep 26.

Abstract

Alzheimer's disease (AD) is a degenerative brain disease that affects millions of people around the world. As populations in the United States and worldwide age, the prevalence of Alzheimer's disease will only increase. In turn, the social and financial costs of AD will create a difficult environment for many families and caregivers across the globe. By combining genetic information, brain scans, and clinical data, gathered over time through the Alzheimer's Disease Neuroimaging Initiative (ADNI), we propose a new Joint High-Order Multi-Modal Multi-Task Feature Learning method to predict the cognitive performance and diagnosis of patients with and without AD.

Keywords: Alzheimer’s disease; Longitudinal; Multi-modal; Tensor.

MeSH terms

  • Algorithms*
  • Alzheimer Disease* / diagnostic imaging
  • Cognitive Dysfunction
  • Disease Progression
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Machine Learning
  • Neuroimaging* / methods
  • Pattern Recognition, Automated / methods
  • Reproducibility of Results
  • Sensitivity and Specificity