Breakthrough Moments: Genome Editing and Organoids

Jatin Roper; Ömer H Yilmaz

doi:10.1016/j.stem.2019.05.008

Breakthrough Moments: Genome Editing and Organoids

Cell Stem Cell. 2019 Jun 6;24(6):841-842. doi: 10.1016/j.stem.2019.05.008.

Authors

Jatin Roper¹, Ömer H Yilmaz²

Affiliations

¹ Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC, USA. Electronic address: jatin.roper@duke.edu.
² The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA. Electronic address: ohyilmaz@mit.edu.

PMID: 31173713
DOI: 10.1016/j.stem.2019.05.008

Abstract

Six years ago, Schwank et al. (2013) adapted CRISPR-Cas9 and organoid technology to repair genetic diseases in patient-derived tissues. We shine a spotlight on how this work has inspired the development of tools to study and correct genetic diseases in experimental systems, with the ultimate goal of treating human disease.

MeSH terms

Animals
CRISPR-Cas Systems
Disease Models, Animal
Gene Editing / methods*
Genetic Diseases, Inborn / genetics
Genetic Diseases, Inborn / pathology*
Genetic Therapy / methods*
Humans
Organoids / pathology*
Organoids / physiology

Abstract

MeSH terms

Grants and funding