Anti-leukemia effect of vitamin K3 is mediated through mitochondrial complexes I and II

Leuk Lymphoma. 2019 Dec;60(12):3071-3074. doi: 10.1080/10428194.2019.1620940. Epub 2019 Jun 4.

Authors

Medhat Ibrahim¹, Nilmini Mendis¹, Alessia Roma¹, Preethi Jayanth¹, Mark D Minden², Paul A Spagnuolo¹

Affiliations

¹ Department of Food Science, University of Guelph, Guelph, Canada.
² Princess Margaret Cancer Center, Ontario Cancer Institute, Toronto, Canada.

PMID: 31164029
DOI: 10.1080/10428194.2019.1620940

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Survival / drug effects
Dose-Response Relationship, Drug
Electron Transport Complex I / metabolism*
Electron Transport Complex II / metabolism*
Humans
Leukemia
Mitochondria / drug effects
Mitochondria / metabolism
Reactive Oxygen Species / metabolism
Vitamin K 3 / pharmacology*

Substances

Antineoplastic Agents
Reactive Oxygen Species
Vitamin K 3
Electron Transport Complex II
Electron Transport Complex I