Effect of mosapride on ruminal motility in cattle

J Vet Med Sci. 2019 Jul 19;81(7):1017-1020. doi: 10.1292/jvms.19-0196. Epub 2019 Jun 3.

Abstract

This study aimed to assess the effects of mosapride at various dosages on ruminal motility in cattle and the absorption kinetics of mosapride in cattle. Mosapride was rapidly absorbed after oral administration in cattle. Oral administration at dosages of 1, 3, and 10 mg/kg resulted in a dose-dependent increase in the detection time. At the 1 mg/kg dose, the motility index of rumen in cattle significantly increased at 60, 70, and 80 min (134 ± 20, 168 ± 37, 173 ± 45%, respectively), compared with that of the control. The administration of mosapride in cattle did not cause any subsequent adverse clinical signs or blood test abnormalities. It was suggested that mosapride enhanced ruminal motility without adverse effects in cattle.

Keywords: cattle; mosapride; oral administration; ruminal motility.

MeSH terms

  • Administration, Oral
  • Animals
  • Benzamides / administration & dosage*
  • Benzamides / pharmacology*
  • Cattle*
  • Female
  • Gastrointestinal Agents / administration & dosage
  • Gastrointestinal Agents / pharmacology*
  • Gastrointestinal Motility / drug effects*
  • Morpholines / administration & dosage*
  • Morpholines / pharmacology*
  • Rumen / drug effects

Substances

  • Benzamides
  • Gastrointestinal Agents
  • Morpholines
  • mosapride