Prevention of pre-eclampsia after infertility treatment: Preconceptional minimalisation of risk factors

Hanna Hürter; Shane Vontelin van Breda; Lenka Vokalova; Marlene Brandl; Marc Baumann; Irene Hösli; Evelin Annegret Huhn; Christian De Geyter; Simona W Rossi; Olav Lapaire

doi:10.1016/j.beem.2019.05.001

Prevention of pre-eclampsia after infertility treatment: Preconceptional minimalisation of risk factors

Best Pract Res Clin Endocrinol Metab. 2019 Feb;33(1):127-132. doi: 10.1016/j.beem.2019.05.001. Epub 2019 May 15.

Authors

Affiliations

¹ Department of Obstetrics, University Women's Hospital, University of Basel, Basel, Switzerland.
² Department of Biomedicine (DBM), University Hospital, University of Basel, Basel, Switzerland.
³ Department of Obstetrics and Gynaecology, University Hospital Bern, Bern, Switzerland.
⁴ Department of Obstetrics, University Women's Hospital, University of Basel, Basel, Switzerland; Department of Biomedicine (DBM), University Hospital, University of Basel, Basel, Switzerland.
⁵ Reproductive Medicine and Gynecological Endocrinology (RME), University Hospital, University of Basel, Vogesenstrasse 124, 4031, Basel, Switzerland; Department of Biomedicine (DBM), University Hospital, University of Basel, Basel, Switzerland.
⁶ Department of Obstetrics, University Women's Hospital, University of Basel, Basel, Switzerland; Department of Biomedicine (DBM), University Hospital, University of Basel, Basel, Switzerland. Electronic address: olav.lapaire@usb.ch.

PMID: 31130446
DOI: 10.1016/j.beem.2019.05.001

Abstract

Although an increased risk of pre-eclampsia in pregnancies conceived after infertility treatment has been reported, it remains unknown whether preconceptional minimalisation of known risk factors would help in preventing pre-eclamsia. Obesity and preconceptional blood pressure are discussed as major risks for the development of pre-eclampsia and low doses of aspirins, folic acid, statins and metformin are discussed as potential preventive treatments to decrease the risk of pre-eclampsia. In the present review we discuss whether present-day reproductive medicine could progress towards complication-free pregnancy.

Keywords: blood pressure; infertility; obesity; pre-eclampsia; preconception; pregnancy.

Publication types

Review

MeSH terms

Female
Humans
Infertility / therapy*
Pre-Eclampsia / etiology
Pre-Eclampsia / prevention & control*
Preconception Care / methods*
Pregnancy
Pregnancy Complications / etiology
Pregnancy Complications / prevention & control
Reproductive Techniques, Assisted / adverse effects*
Risk Factors