Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV

J Pediatric Infect Dis Soc. 2020 Apr 30;9(2):253-256. doi: 10.1093/jpids/piz034.

Abstract

Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor-based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation.

Keywords: HIV; adherence; hair concentration; second-line ART; virologic failure; virologic resuppression.

MeSH terms

  • Adolescent
  • Anti-Retroviral Agents / therapeutic use
  • Asia, Southeastern
  • CD4 Lymphocyte Count
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV Protease / genetics*
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Longitudinal Studies
  • Male
  • Mutation*
  • Treatment Failure
  • Viral Load

Substances

  • Anti-Retroviral Agents
  • HIV Protease Inhibitors
  • HIV Protease