A Factor Two Improvement in High-Field Dynamic Nuclear Polarization from Gd(III) Complexes by Design

Gabriele Stevanato; Dominik Józef Kubicki; Georges Menzildjian; Anne-Sophie Chauvin; Katharina Keller; Maxim Yulikov; Gunnar Jeschke; Marinella Mazzanti; Lyndon Emsley

doi:10.1021/jacs.9b03723

A Factor Two Improvement in High-Field Dynamic Nuclear Polarization from Gd(III) Complexes by Design

J Am Chem Soc. 2019 Jun 5;141(22):8746-8751. doi: 10.1021/jacs.9b03723. Epub 2019 May 24.

Authors

Gabriele Stevanato¹, Dominik Józef Kubicki¹, Georges Menzildjian¹, Anne-Sophie Chauvin², Katharina Keller³, Maxim Yulikov³, Gunnar Jeschke³, Marinella Mazzanti², Lyndon Emsley¹

Affiliations

¹ Laboratory of Magnetic Resonance, Institut des Sciences et Ingéniere Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland.
² Group of Coordination Chemistry, Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland.
³ Laboratory of Inorganic Chemistry, Department of Chemistry, Laboratory , ETH Zurich , 8093 Zurich , Switzerland.

PMID: 31117477
DOI: 10.1021/jacs.9b03723

Abstract

Gadolinium(III) complexes have recently been demonstrated to have potential as polarizing agents for high-field dynamic nuclear polarization (DNP) NMR spectroscopy. By tailoring the ligand design to reduce the zero-field splitting (ZFS), we demonstrate a quadratic improvement in DNP through the investigation of a stable, water-soluble, narrow-line Gd(III) complex, [Gd(tpatcn)], doubling the magic-angle-spinning DNP enhancement of the previous state-of-the-art [Gd(dota)(H₂O)]^- at 9.4 T and 100 K.

Publication types

Research Support, Non-U.S. Gov't