Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus-Infected Human Blood-Brain Barrier Endothelial Cells

J Infect Dis. 2019 Sep 26;220(9):1539-1540. doi: 10.1093/infdis/jiz276.

Authors

Linda Hueston¹, Georges E Grau², Suresh Mahalingam³

Affiliations

¹ Arbovirus Emerging Disease Unit, CIDMLS-ICPMR, NSW Health Pathology, Westmead Hospital, Westmead.
² Vascular Immunology Unit, Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney.
³ Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Australia.

PMID: 31116849
DOI: 10.1093/infdis/jiz276

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Blood-Brain Barrier
Cytokines
Endothelial Cells
Humans
Inflammasomes
Inflammation
Interleukin 1 Receptor Antagonist Protein
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
Zika Virus Infection*
Zika Virus*

Substances

Cytokines
Inflammasomes
Interleukin 1 Receptor Antagonist Protein
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human