An Optical Exposé of Cortical Function

Naomi Shvedov; David J Margolis

doi:10.1016/j.tins.2019.05.003

An Optical Exposé of Cortical Function

Trends Neurosci. 2019 Aug;42(8):511-513. doi: 10.1016/j.tins.2019.05.003. Epub 2019 May 17.

Authors

Naomi Shvedov¹, David J Margolis²

Affiliations

¹ Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
² Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address: david.margolis@rutgers.edu.

PMID: 31109741
DOI: 10.1016/j.tins.2019.05.003

Abstract

Neural imaging benefits from optical access to widespread brain areas. A recent study (Ghanbari et al. Nat. Commun. 2019;10;1500) introduces See-Shell, a transparent polymer skull that reveals the entire dorsal cortex in mice. See-Shells are 3D-printed, customizable, and modifiable for combined neural recording and manipulation, offering advantages for high-resolution, multiscale measures of in vivo brain function.

Keywords: brain function; imaging; microscopy; neural circuits; plasticity; see-shell.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Animals
Brain
Cerebral Cortex
Mice
Polymers*
Skull*

Substances

Polymers

Grants and funding

R01 NS094450/NS/NINDS NIH HHS/United States